Inflammation and Obesity-associated Disease View Homepage


Ontology type: schema:MedicalStudy     


Clinical Trial Info

YEARS

2014-2019

ABSTRACT

Visceral obesity and adipose inflammation is considered a driving force of obesity-related systemic disease, e.g. liver cirrhosis and chronic kidney disease (CKD). Inflammatory resolution is actively regulated by specialized pro-resolving mediators (SPMs), including the endogenous eicosanoid LXA4. Impairment of SPMs may underlie development of obesity-related pathology.We hypothesize that obese patients who develop obesity-related liver and kidney disease do so because they suffer from impaired endogenous production of pro-resolving lipids. This will result in aggravated adipose inflammation, which causes systemic pathologies such as kidney disease. We thus wish to investigate adipose inflammation and the pro-resolving lipid profile of obese subjects with and without CKD and liver disease. We also aim to investigate whether LXA4, LXB4 and other anti-inflammatory agents (such as AICAR) can alter the phenotype of human adipose macrophages in ex vivo tissue culture. More... »

URL

https://clinicaltrials.gov/show/NCT02322073

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