Characterization of Phenotypic and Genotypic Regressors View Homepage


Ontology type: schema:MedicalStudy     


Clinical Trial Info

YEARS

2010-

ABSTRACT

The influence of genes on addictive and neuropsychiatric disorders is complex, especially given that multiple genes likely influence certain behaviors that are correlated with addiction. Researchers are interested in looking at the genetic information of individuals who are enrolled on National Institute for Drug Abuse studies to investigate specific genetic variants that may be related to substance abuse. Researchers will study the effects of genes on several aspects of thinking such as attention, memory, decision making, problem solving, learning, and emotional feelings, and investigate the ways in which genetic information affects addictive behaviors and substance abuse. In addition, researchers will study how genes may explain differences in imaging data in substance users. Objectives: - To collect genetic information for research on genetic aspects of addiction and substance abuse. Eligibility: - Adults age 18 or older - (1) healthy, non-drug-using nonsmokers, - (2) healthy smokers, - (3) healthy individuals dependent on other commonly abused drugs, and - (4) individuals with other psychiatric disorders. - Participants must be right-handed, and must be enrolled in another National Institute on Drug Abuse, Intramural Research Program imaging protocol. Design: - This study involves one to two visits to National Institute on Drug Abuse, Intramural Research Program that may be separate from the participant s current research protocol study visits or on the same day as those visits. . - Participants will provide a blood sample and complete questionnaires about mood, memory, and learning. - Participants may also be asked to do a few tasks, such as playing computer games involving coin tosses and money management, or responding to questions on a computer screen. Detailed Description Objective: To determine genetic variants as well as behavioral measures across different study group populations. Results of these will be used as regressors to help explain inter-individual differences in data collected across IRP protocols. Study Population: The study population will include 1) healthy non-smoking, non-drug dependent participants 2) healthy nicotine-dependent individuals 3) healthy individuals dependent on other commonly abused drugs 4) individuals with other psychiatric disorders and 5) treatment-seeking individuals dependent on nicotine or other commonly abused drugs. Participants must be under evaluation for another NIDA-IRP protocol, generally healthy, and age 18 or older. Design: This study will require 1 visit (approximately 4-6 hours) to the NIDA-IRP, which may be in conjunction with another NIDA-IRP study. The characterization instruments are divided into two sections: Common Instruments and Additional Instruments. Common Instruments include instruments in common with what is done under a similar protocol at NIAAA. All participants will complete these instruments along with the blood sample, Delayed Discounting task and MRI scan. The completion of these items will define a completer of this protocol. Subjects will have the option to complete the study in multiple visits if they choose. After being consented into the study, the participant will be asked to submit a blood sample, complete various questionnaires, characterization instruments and several behavioral tasks. Blood will only be drawn once, provided there are no technical problems (such as sample damage during collection, preparation, shipping or assay) requiring a repeat draw. Participants in more than one NIDA-IRP protocol will be asked to repeat a few of the time-sensitive questionnaires in this protocol during subsequent MRI visits, as required by other IRP imaging protocols in which the subject may be participating. Data acquired in this protocol will be compared to data acquired in other NIDAIRP protocols. Outcome Measures: The primary outcome measures in this study are the genetic, behavioral and phenotypic factors that are related to addiction. Secondary outcome measures are to compare the genetic, behavioral and phenotypic factors to imaging and behavioral data acquired across other IRP protocols. More... »

URL

https://clinicaltrials.gov/show/NCT01148381

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3468", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "description": "The influence of genes on addictive and neuropsychiatric disorders is complex, especially given that multiple genes likely influence certain behaviors that are correlated with addiction. Researchers are interested in looking at the genetic information of individuals who are enrolled on National Institute for Drug Abuse studies to investigate specific genetic variants that may be related to substance abuse. Researchers will study the effects of genes on several aspects of thinking such as attention, memory, decision making, problem solving, learning, and emotional feelings, and investigate the ways in which genetic information affects addictive behaviors and substance abuse. In addition, researchers will study how genes may explain differences in imaging data in substance users. Objectives: - To collect genetic information for research on genetic aspects of addiction and substance abuse. Eligibility: - Adults age 18 or older - (1) healthy, non-drug-using nonsmokers, - (2) healthy smokers, - (3) healthy individuals dependent on other commonly abused drugs, and - (4) individuals with other psychiatric disorders. - Participants must be right-handed, and must be enrolled in another National Institute on Drug Abuse, Intramural Research Program imaging protocol. Design: - This study involves one to two visits to National Institute on Drug Abuse, Intramural Research Program that may be separate from the participant s current research protocol study visits or on the same day as those visits. . - Participants will provide a blood sample and complete questionnaires about mood, memory, and learning. - Participants may also be asked to do a few tasks, such as playing computer games involving coin tosses and money management, or responding to questions on a computer screen.\n\nDetailed Description\nObjective: To determine genetic variants as well as behavioral measures across different study group populations. Results of these will be used as regressors to help explain inter-individual differences in data collected across IRP protocols. Study Population: The study population will include 1) healthy non-smoking, non-drug dependent participants 2) healthy nicotine-dependent individuals 3) healthy individuals dependent on other commonly abused drugs 4) individuals with other psychiatric disorders and 5) treatment-seeking individuals dependent on nicotine or other commonly abused drugs. Participants must be under evaluation for another NIDA-IRP protocol, generally healthy, and age 18 or older. Design: This study will require 1 visit (approximately 4-6 hours) to the NIDA-IRP, which may be in conjunction with another NIDA-IRP study. The characterization instruments are divided into two sections: Common Instruments and Additional Instruments. Common Instruments include instruments in common with what is done under a similar protocol at NIAAA. All participants will complete these instruments along with the blood sample, Delayed Discounting task and MRI scan. The completion of these items will define a completer of this protocol. Subjects will have the option to complete the study in multiple visits if they choose. After being consented into the study, the participant will be asked to submit a blood sample, complete various questionnaires, characterization instruments and several behavioral tasks. Blood will only be drawn once, provided there are no technical problems (such as sample damage during collection, preparation, shipping or assay) requiring a repeat draw. Participants in more than one NIDA-IRP protocol will be asked to repeat a few of the time-sensitive questionnaires in this protocol during subsequent MRI visits, as required by other IRP imaging protocols in which the subject may be participating. Data acquired in this protocol will be compared to data acquired in other NIDAIRP protocols. Outcome Measures: The primary outcome measures in this study are the genetic, behavioral and phenotypic factors that are related to addiction. Secondary outcome measures are to compare the genetic, behavioral and phenotypic factors to imaging and behavioral data acquired across other IRP protocols.", 
    "id": "sg:clinicaltrial.NCT01148381", 
    "keywords": [
      "sample", 
      "imaging", 
      "healthy individual", 
      "blood", 
      "eligibility", 
      "problem solving", 
      "intramural research program", 
      "IRP", 
      "repeat", 
      "difference", 
      "questionnaire", 
      "preparation", 
      "management", 
      "task", 
      "National Institute on Drug Abuse", 
      "imaging protocol", 
      "video game", 
      "different study", 
      "protocol", 
      "collection", 
      "certain behavior", 
      "behavioral data", 
      "instrument", 
      "genetic variant", 
      "assay", 
      "healthy smoker", 
      "behavioral measure", 
      "regressors", 
      "primary outcome measure", 
      "Secondary outcome measure", 
      "drug", 
      "specific genetic variant", 
      "study population", 
      "individual", 
      "adult", 
      "behavioral task", 
      "Affect", 
      "dependent individual", 
      "non-drug", 
      "completion", 
      "MRI", 
      "memory", 
      "psychiatric disorder", 
      "addiction", 
      "neuropsychiatric disorder", 
      "option", 
      "genetic aspect", 
      "National Institute", 
      "Substance-Related Disorder", 
      "age 18", 
      "imaging data", 
      "visit", 
      "inter-individual difference", 
      "blood sample", 
      "completers", 
      "computer screen", 
      "treatment-seeking", 
      "multiple gene", 
      "abused drug", 
      "similar protocol", 
      "nicotine", 
      "research protocol", 
      "complete questionnaire", 
      "complex", 
      "additional instrument", 
      "Evaluation Study as Topic", 
      "non-smoking", 
      "section", 
      "aspect", 
      "coin toss", 
      "gene", 
      "substance user", 
      "addictive behavior", 
      "Outcome Assessment", 
      "National Institute on Alcohol Abuse and Alcoholism", 
      "technical problem", 
      "genetic information"
    ], 
    "name": "Characterization of Phenotypic and Genotypic Regressors", 
    "sameAs": [
      "https://app.dimensions.ai/details/clinical_trial/NCT01148381"
    ], 
    "sdDataset": "clinical_trials", 
    "sdDatePublished": "2019-03-07T15:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "file:///pack/app/us_ct_data_00009.json", 
    "sponsor": [
      {
        "id": "https://www.grid.ac/institutes/grid.420090.f", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.410305.3", 
        "type": "Organization"
      }
    ], 
    "startDate": "2010-06-01T00:00:00Z", 
    "subjectOf": [
      {
        "id": "https://doi.org/10.1348/014466500163077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037452187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/6.4.577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043433322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4002154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052582618", 
          "https://doi.org/10.1038/sj.mp.4002154"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "type": "MedicalStudy", 
    "url": "https://clinicaltrials.gov/show/NCT01148381"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/clinicaltrial.NCT01148381'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/clinicaltrial.NCT01148381'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/clinicaltrial.NCT01148381'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/clinicaltrial.NCT01148381'


 

This table displays all metadata directly associated to this object as RDF triples.

107 TRIPLES      15 PREDICATES      95 URIs      85 LITERALS      1 BLANK NODES

Subject Predicate Object
1 sg:clinicaltrial.NCT01148381 schema:about anzsrc-for:3468
2 schema:description The influence of genes on addictive and neuropsychiatric disorders is complex, especially given that multiple genes likely influence certain behaviors that are correlated with addiction. Researchers are interested in looking at the genetic information of individuals who are enrolled on National Institute for Drug Abuse studies to investigate specific genetic variants that may be related to substance abuse. Researchers will study the effects of genes on several aspects of thinking such as attention, memory, decision making, problem solving, learning, and emotional feelings, and investigate the ways in which genetic information affects addictive behaviors and substance abuse. In addition, researchers will study how genes may explain differences in imaging data in substance users. Objectives: - To collect genetic information for research on genetic aspects of addiction and substance abuse. Eligibility: - Adults age 18 or older - (1) healthy, non-drug-using nonsmokers, - (2) healthy smokers, - (3) healthy individuals dependent on other commonly abused drugs, and - (4) individuals with other psychiatric disorders. - Participants must be right-handed, and must be enrolled in another National Institute on Drug Abuse, Intramural Research Program imaging protocol. Design: - This study involves one to two visits to National Institute on Drug Abuse, Intramural Research Program that may be separate from the participant s current research protocol study visits or on the same day as those visits. . - Participants will provide a blood sample and complete questionnaires about mood, memory, and learning. - Participants may also be asked to do a few tasks, such as playing computer games involving coin tosses and money management, or responding to questions on a computer screen. Detailed Description Objective: To determine genetic variants as well as behavioral measures across different study group populations. Results of these will be used as regressors to help explain inter-individual differences in data collected across IRP protocols. Study Population: The study population will include 1) healthy non-smoking, non-drug dependent participants 2) healthy nicotine-dependent individuals 3) healthy individuals dependent on other commonly abused drugs 4) individuals with other psychiatric disorders and 5) treatment-seeking individuals dependent on nicotine or other commonly abused drugs. Participants must be under evaluation for another NIDA-IRP protocol, generally healthy, and age 18 or older. Design: This study will require 1 visit (approximately 4-6 hours) to the NIDA-IRP, which may be in conjunction with another NIDA-IRP study. The characterization instruments are divided into two sections: Common Instruments and Additional Instruments. Common Instruments include instruments in common with what is done under a similar protocol at NIAAA. All participants will complete these instruments along with the blood sample, Delayed Discounting task and MRI scan. The completion of these items will define a completer of this protocol. Subjects will have the option to complete the study in multiple visits if they choose. After being consented into the study, the participant will be asked to submit a blood sample, complete various questionnaires, characterization instruments and several behavioral tasks. Blood will only be drawn once, provided there are no technical problems (such as sample damage during collection, preparation, shipping or assay) requiring a repeat draw. Participants in more than one NIDA-IRP protocol will be asked to repeat a few of the time-sensitive questionnaires in this protocol during subsequent MRI visits, as required by other IRP imaging protocols in which the subject may be participating. Data acquired in this protocol will be compared to data acquired in other NIDAIRP protocols. Outcome Measures: The primary outcome measures in this study are the genetic, behavioral and phenotypic factors that are related to addiction. Secondary outcome measures are to compare the genetic, behavioral and phenotypic factors to imaging and behavioral data acquired across other IRP protocols.
3 schema:keywords Affect
4 Evaluation Study as Topic
5 IRP
6 MRI
7 National Institute
8 National Institute on Alcohol Abuse and Alcoholism
9 National Institute on Drug Abuse
10 Outcome Assessment
11 Secondary outcome measure
12 Substance-Related Disorder
13 abused drug
14 addiction
15 addictive behavior
16 additional instrument
17 adult
18 age 18
19 aspect
20 assay
21 behavioral data
22 behavioral measure
23 behavioral task
24 blood
25 blood sample
26 certain behavior
27 coin toss
28 collection
29 complete questionnaire
30 completers
31 completion
32 complex
33 computer screen
34 dependent individual
35 difference
36 different study
37 drug
38 eligibility
39 gene
40 genetic aspect
41 genetic information
42 genetic variant
43 healthy individual
44 healthy smoker
45 imaging
46 imaging data
47 imaging protocol
48 individual
49 instrument
50 inter-individual difference
51 intramural research program
52 management
53 memory
54 multiple gene
55 neuropsychiatric disorder
56 nicotine
57 non-drug
58 non-smoking
59 option
60 preparation
61 primary outcome measure
62 problem solving
63 protocol
64 psychiatric disorder
65 questionnaire
66 regressors
67 repeat
68 research protocol
69 sample
70 section
71 similar protocol
72 specific genetic variant
73 study population
74 substance user
75 task
76 technical problem
77 treatment-seeking
78 video game
79 visit
80 schema:name Characterization of Phenotypic and Genotypic Regressors
81 schema:sameAs https://app.dimensions.ai/details/clinical_trial/NCT01148381
82 schema:sdDatePublished 2019-03-07T15:23
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Nfabbffdcaf3c4bebba46c5df6d47106b
85 schema:sponsor https://www.grid.ac/institutes/grid.410305.3
86 https://www.grid.ac/institutes/grid.420090.f
87 schema:startDate 2010-06-01T00:00:00Z
88 schema:subjectOf sg:pub.10.1038/sj.mp.4002154
89 https://doi.org/10.1093/hmg/6.4.577
90 https://doi.org/10.1348/014466500163077
91 schema:url https://clinicaltrials.gov/show/NCT01148381
92 sgo:license sg:explorer/license/
93 sgo:sdDataset clinical_trials
94 rdf:type schema:MedicalStudy
95 Nfabbffdcaf3c4bebba46c5df6d47106b schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 anzsrc-for:3468 schema:inDefinedTermSet anzsrc-for:
98 rdf:type schema:DefinedTerm
99 sg:pub.10.1038/sj.mp.4002154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052582618
100 https://doi.org/10.1038/sj.mp.4002154
101 rdf:type schema:CreativeWork
102 https://doi.org/10.1093/hmg/6.4.577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043433322
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1348/014466500163077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037452187
105 rdf:type schema:CreativeWork
106 https://www.grid.ac/institutes/grid.410305.3 schema:Organization
107 https://www.grid.ac/institutes/grid.420090.f schema:Organization
 




Preview window. Press ESC to close (or click here)


...