Initialization of Methadone in Primary Care; a Randomized Intervention Research for Preventing HCV Transmission Practices. ANRS Methaville View Homepage


Ontology type: schema:MedicalStudy     


Clinical Trial Info

YEARS

2009-2011

ABSTRACT

The rapid scale up of opioid substitution treatment (OST) for drug users mainly achieved through the possibility of prescribing buprenorphine in primary care has been successful in reducing HIV prevalence among drug users but still inadequate for reducing the spread of HCV. To date, methadone in France can only be initialised in drug centres but GPs can prescribe methadone after stabilisation of dosages. This study was born as an answer to a request from the French Minister of Health that supports the initialisation of methadone in primary care in order to improve coverage by OST (now 70%) in drug users. Detailed Description We aimed to test the non inferiority of the proportion of non users of street-opioids after one year of treatment in patients inducted in primary care (PC) vs.those inducted in a specialised center for substance dependence (CSAPA). In this multisite, open-label, randomised controlled non-inferiority trial, opioid dependent individuals were randomized to start methadone either in PC or in a CSAPA. After stabilization of methadone dosage (~2 weeks), patients could change arm. Follow-up assessments through medical questionnaires and phone interviews was scheduled at month 0 (M0, enrolment) M3, M6, M12. The opiate treatment index (OTI) was used for computing the proportion of patients reporting no use of street opioids in the last month at M12 (primary outcome) in those inducted in PC or in a CSAPA and the non inferiority margins. Primary analysis was by intention to treat (ITT) More... »

URL

https://clinicaltrials.gov/show/NCT00657397

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3177", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "description": "The rapid scale up of opioid substitution treatment (OST) for drug users mainly achieved through the possibility of prescribing buprenorphine in primary care has been successful in reducing HIV prevalence among drug users but still inadequate for reducing the spread of HCV. To date, methadone in France can only be initialised in drug centres but GPs can prescribe methadone after stabilisation of dosages. This study was born as an answer to a request from the French Minister of Health that supports the initialisation of methadone in primary care in order to improve coverage by OST (now 70%) in drug users.\n\nDetailed Description\nWe aimed to test the non inferiority of the proportion of non users of street-opioids after one year of treatment in patients inducted in primary care (PC) vs.those inducted in a specialised center for substance dependence (CSAPA). In this multisite, open-label, randomised controlled non-inferiority trial, opioid dependent individuals were randomized to start methadone either in PC or in a CSAPA. After stabilization of methadone dosage (~2 weeks), patients could change arm. Follow-up assessments through medical questionnaires and phone interviews was scheduled at month 0 (M0, enrolment) M3, M6, M12. The opiate treatment index (OTI) was used for computing the proportion of patients reporting no use of street opioids in the last month at M12 (primary outcome) in those inducted in PC or in a CSAPA and the non inferiority margins. Primary analysis was by intention to treat (ITT)", 
    "endDate": "2011-12-01T00:00:00Z", 
    "id": "sg:clinicaltrial.NCT00657397", 
    "keywords": [
      "initialization", 
      "methadone", 
      "Primary Health Care", 
      "randomized intervention", 
      "ANR", 
      "RAPID", 
      "Opiate Substitution Treatment", 
      "drug user", 
      "possibility", 
      "buprenorphine", 
      "HIV prevalence", 
      "HCV", 
      "date", 
      "France", 
      "drug", 
      "GPS", 
      "stabilisation", 
      "dosage", 
      "request", 
      "minister", 
      "coverage", 
      "non-inferiority", 
      "proportion", 
      "non-users", 
      "street", 
      "patient", 
      "dependence", 
      "multisite", 
      "opioid-dependent individual", 
      "care", 
      "stabilization", 
      "arm", 
      "follow-up assessment", 
      "questionnaire", 
      "phone interview", 
      "M0", 
      "enrollment", 
      "M3", 
      "M6", 
      "opiate", 
      "primary outcome", 
      "primary analysis", 
      "intention"
    ], 
    "name": "Initialization of Methadone in Primary Care; a Randomized Intervention Research for Preventing HCV Transmission Practices. ANRS Methaville", 
    "sameAs": [
      "https://app.dimensions.ai/details/clinical_trial/NCT00657397"
    ], 
    "sdDataset": "clinical_trials", 
    "sdDatePublished": "2019-03-07T15:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "file:///pack/app/us_ct_data_00005.json", 
    "sponsor": [
      {
        "id": "https://www.grid.ac/institutes/grid.453032.3", 
        "type": "Organization"
      }
    ], 
    "startDate": "2009-01-01T00:00:00Z", 
    "subjectOf": [
      {
        "id": "sg:pub.10.1186/1471-2458-12-488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004037315", 
          "https://doi.org/10.1186/1471-2458-12-488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drugpo.2016.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005230294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drugalcdep.2013.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009070431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12954-016-0100-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025376810", 
          "https://doi.org/10.1186/s12954-016-0100-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1747-597x-9-37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035496232", 
          "https://doi.org/10.1186/1747-597x-9-37"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0112328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048471393"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "type": "MedicalStudy", 
    "url": "https://clinicaltrials.gov/show/NCT00657397"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/clinicaltrial.NCT00657397'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/clinicaltrial.NCT00657397'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/clinicaltrial.NCT00657397'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/clinicaltrial.NCT00657397'


 

This table displays all metadata directly associated to this object as RDF triples.

83 TRIPLES      16 PREDICATES      64 URIs      52 LITERALS      1 BLANK NODES

Subject Predicate Object
1 sg:clinicaltrial.NCT00657397 schema:about anzsrc-for:3177
2 schema:description The rapid scale up of opioid substitution treatment (OST) for drug users mainly achieved through the possibility of prescribing buprenorphine in primary care has been successful in reducing HIV prevalence among drug users but still inadequate for reducing the spread of HCV. To date, methadone in France can only be initialised in drug centres but GPs can prescribe methadone after stabilisation of dosages. This study was born as an answer to a request from the French Minister of Health that supports the initialisation of methadone in primary care in order to improve coverage by OST (now 70%) in drug users. Detailed Description We aimed to test the non inferiority of the proportion of non users of street-opioids after one year of treatment in patients inducted in primary care (PC) vs.those inducted in a specialised center for substance dependence (CSAPA). In this multisite, open-label, randomised controlled non-inferiority trial, opioid dependent individuals were randomized to start methadone either in PC or in a CSAPA. After stabilization of methadone dosage (~2 weeks), patients could change arm. Follow-up assessments through medical questionnaires and phone interviews was scheduled at month 0 (M0, enrolment) M3, M6, M12. The opiate treatment index (OTI) was used for computing the proportion of patients reporting no use of street opioids in the last month at M12 (primary outcome) in those inducted in PC or in a CSAPA and the non inferiority margins. Primary analysis was by intention to treat (ITT)
3 schema:endDate 2011-12-01T00:00:00Z
4 schema:keywords ANR
5 France
6 GPS
7 HCV
8 HIV prevalence
9 M0
10 M3
11 M6
12 Opiate Substitution Treatment
13 Primary Health Care
14 RAPID
15 arm
16 buprenorphine
17 care
18 coverage
19 date
20 dependence
21 dosage
22 drug
23 drug user
24 enrollment
25 follow-up assessment
26 initialization
27 intention
28 methadone
29 minister
30 multisite
31 non-inferiority
32 non-users
33 opiate
34 opioid-dependent individual
35 patient
36 phone interview
37 possibility
38 primary analysis
39 primary outcome
40 proportion
41 questionnaire
42 randomized intervention
43 request
44 stabilisation
45 stabilization
46 street
47 schema:name Initialization of Methadone in Primary Care; a Randomized Intervention Research for Preventing HCV Transmission Practices. ANRS Methaville
48 schema:sameAs https://app.dimensions.ai/details/clinical_trial/NCT00657397
49 schema:sdDatePublished 2019-03-07T15:23
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher Na4dafad79ce74a1485ed5b1516d09da0
52 schema:sponsor https://www.grid.ac/institutes/grid.453032.3
53 schema:startDate 2009-01-01T00:00:00Z
54 schema:subjectOf sg:pub.10.1186/1471-2458-12-488
55 sg:pub.10.1186/1747-597x-9-37
56 sg:pub.10.1186/s12954-016-0100-7
57 https://doi.org/10.1016/j.drugalcdep.2013.10.018
58 https://doi.org/10.1016/j.drugpo.2016.08.005
59 https://doi.org/10.1371/journal.pone.0112328
60 schema:url https://clinicaltrials.gov/show/NCT00657397
61 sgo:license sg:explorer/license/
62 sgo:sdDataset clinical_trials
63 rdf:type schema:MedicalStudy
64 Na4dafad79ce74a1485ed5b1516d09da0 schema:name Springer Nature - SN SciGraph project
65 rdf:type schema:Organization
66 anzsrc-for:3177 schema:inDefinedTermSet anzsrc-for:
67 rdf:type schema:DefinedTerm
68 sg:pub.10.1186/1471-2458-12-488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004037315
69 https://doi.org/10.1186/1471-2458-12-488
70 rdf:type schema:CreativeWork
71 sg:pub.10.1186/1747-597x-9-37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035496232
72 https://doi.org/10.1186/1747-597x-9-37
73 rdf:type schema:CreativeWork
74 sg:pub.10.1186/s12954-016-0100-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025376810
75 https://doi.org/10.1186/s12954-016-0100-7
76 rdf:type schema:CreativeWork
77 https://doi.org/10.1016/j.drugalcdep.2013.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009070431
78 rdf:type schema:CreativeWork
79 https://doi.org/10.1016/j.drugpo.2016.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005230294
80 rdf:type schema:CreativeWork
81 https://doi.org/10.1371/journal.pone.0112328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048471393
82 rdf:type schema:CreativeWork
83 https://www.grid.ac/institutes/grid.453032.3 schema:Organization
 




Preview window. Press ESC to close (or click here)


...