Physical Activity and Its Components in Relation to Plasma Inflammatory Markers of Cancer Risk Among Chinese Adults View Homepage


Ontology type: schema:MedicalStudy     


Clinical Trial Info

YEARS

2005-

ABSTRACT

This protocol is a sub-study of the ongoing "Protect Health and Reduce Cancer Risk" study conducted in Shanghai, China, and sponsored by the Shanghai Cancer Institute, Vanderbilt University, and the National Cancer Institute. The parent study is designed to examine the relationship of diet, lifestyle, occupational, and environmental risk factors, as well as genetic variation, to cancer incidence in a large cohort of men in women between 40 and 70 years of age. The current sub-study will assess the validity and reliability of a new physical activity questionnaire for use in the parent study and to evaluate whether different types of activity and the frequency, intensity, and duration of activity are associated with markers that have been linked to cancer risk, such as C-reactive protein, interleukin 6 and soluble tumor necrosis factor alpha. Participants in the current 12-month study are selected from among men and women participating in the "Protect Health and Reduce Cancer Risk" study. Participants keep a diary of their physical activity and complete two 30-minute interviews about their physical activity, one at the beginning and one at the end of the study period. Every 3 months for 7 consecutive days, they wear a pager-sized activity monitor on their waist that records their physical activity patterns during that period of time. They provide blood and urine samples four times during the study and, at the end of the study, undergo a health examination that includes an electrocardiogram, body composition measurement, and physical fitness test. The fitness test is a step-test consisting of 3-minute stages in which the subject successively increases the stepping speed until reaching 85 percent of his or her predicted maximal heart rate. Blood and urine samples are analyzed for levels of nutrients and certain proteins, and are stored for future studies related to nutrition and physical activity and possibly for genetic studies related to health, nutrition, exercise, or disease. Detailed Description In the past decade, China has experienced fundamental decreases in the populations' physical activity levels, due to increasingly sedentary occupations and lifestyles. However, the transition to a Western lifestyle has not reached the entire Chinese population. The resulting wide range of between-person variation in physical activity provides an unparalleled opportunity for physical activity studies. Although physical activity measurement techniques have evolved considerably over the past years, the main obstacle in quantifying physical activity is the complexity of precisely measuring its individual components, particularly low to moderate-intensity activities. Recently, investigators at Vanderbilt University, the Shanghai Cancer Institute, and the DCEG initiated two prospective population-based cohort studies: the Shanghai Women's Cohort and the Shanghai Men's Cohort. The aim of these studies is to prospectively examine the relations of diet, lifestyle, occupational, and environmental risk factors, as well as genetic variation, to cancer incidence among 75,000 women and 73,000 men, aged 40 to 70 years old, and residing in Shanghai, China. We propose to conduct a study among 600 women and men participating in these two cohort studies. The specific objectives of the current study are to develop a comprehensive physical activity questionnaire and to assess the validity and reliability of this instrument in the Shanghai cohorts using objective measures of physical activity/physical fitness: activity monitors, and the Modified Canadian Aerobic Fitness Test. In addition, we intend to evaluate whether different types and parameters of physical activity are associated with circulating levels of specific inflammatory markers that have been linked to cancer risk. The specific markers are C-reactive protein (CRP), interleukin 6 (IL-6), and soluble tumor necrosis factor alpha (TNF-a). The impact of potentially confounding variables of the association between physical activity and inflammatory markers, such as recent exercise, use of anti-inflammatory drugs, and current or recent infections, will be carefully accounted for in the analysis. More... »

URL

https://clinicaltrials.gov/show/NCT00521651

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3177", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "description": "This protocol is a sub-study of the ongoing \"Protect Health and Reduce Cancer Risk\" study conducted in Shanghai, China, and sponsored by the Shanghai Cancer Institute, Vanderbilt University, and the National Cancer Institute. The parent study is designed to examine the relationship of diet, lifestyle, occupational, and environmental risk factors, as well as genetic variation, to cancer incidence in a large cohort of men in women between 40 and 70 years of age. The current sub-study will assess the validity and reliability of a new physical activity questionnaire for use in the parent study and to evaluate whether different types of activity and the frequency, intensity, and duration of activity are associated with markers that have been linked to cancer risk, such as C-reactive protein, interleukin 6 and soluble tumor necrosis factor alpha. Participants in the current 12-month study are selected from among men and women participating in the \"Protect Health and Reduce Cancer Risk\" study. Participants keep a diary of their physical activity and complete two 30-minute interviews about their physical activity, one at the beginning and one at the end of the study period. Every 3 months for 7 consecutive days, they wear a pager-sized activity monitor on their waist that records their physical activity patterns during that period of time. They provide blood and urine samples four times during the study and, at the end of the study, undergo a health examination that includes an electrocardiogram, body composition measurement, and physical fitness test. The fitness test is a step-test consisting of 3-minute stages in which the subject successively increases the stepping speed until reaching 85 percent of his or her predicted maximal heart rate. Blood and urine samples are analyzed for levels of nutrients and certain proteins, and are stored for future studies related to nutrition and physical activity and possibly for genetic studies related to health, nutrition, exercise, or disease.\n\nDetailed Description\nIn the past decade, China has experienced fundamental decreases in the populations' physical activity levels, due to increasingly sedentary occupations and lifestyles. However, the transition to a Western lifestyle has not reached the entire Chinese population. The resulting wide range of between-person variation in physical activity provides an unparalleled opportunity for physical activity studies. Although physical activity measurement techniques have evolved considerably over the past years, the main obstacle in quantifying physical activity is the complexity of precisely measuring its individual components, particularly low to moderate-intensity activities. Recently, investigators at Vanderbilt University, the Shanghai Cancer Institute, and the DCEG initiated two prospective population-based cohort studies: the Shanghai Women's Cohort and the Shanghai Men's Cohort. The aim of these studies is to prospectively examine the relations of diet, lifestyle, occupational, and environmental risk factors, as well as genetic variation, to cancer incidence among 75,000 women and 73,000 men, aged 40 to 70 years old, and residing in Shanghai, China. We propose to conduct a study among 600 women and men participating in these two cohort studies. The specific objectives of the current study are to develop a comprehensive physical activity questionnaire and to assess the validity and reliability of this instrument in the Shanghai cohorts using objective measures of physical activity/physical fitness: activity monitors, and the Modified Canadian Aerobic Fitness Test. In addition, we intend to evaluate whether different types and parameters of physical activity are associated with circulating levels of specific inflammatory markers that have been linked to cancer risk. The specific markers are C-reactive protein (CRP), interleukin 6 (IL-6), and soluble tumor necrosis factor alpha (TNF-a). The impact of potentially confounding variables of the association between physical activity and inflammatory markers, such as recent exercise, use of anti-inflammatory drugs, and current or recent infections, will be carefully accounted for in the analysis.", 
    "id": "sg:clinicaltrial.NCT00521651", 
    "keywords": [
      "Motor Activity", 
      "component", 
      "relation", 
      "plasma", 
      "inflammatory marker", 
      "adult", 
      "protocol", 
      "sub-study", 
      "cancer risk", 
      "Shanghai", 
      "China", 
      "Cancer Institute", 
      "Vanderbilt University", 
      "National Cancer Institute", 
      "parent study", 
      "diet", 
      "Life Style", 
      "environmental risk factor", 
      "genetic variation", 
      "cancer incidence", 
      "large cohort", 
      "men", 
      "woman", 
      "age", 
      "Reproducibility of Result", 
      "physical activity questionnaire", 
      "different type", 
      "frequency", 
      "intensity", 
      "duration", 
      "marker", 
      "C-reactive protein", 
      "Interleukin-6", 
      "Tumor Necrosis Factor-alpha", 
      "interview", 
      "beginning", 
      "study period", 
      "pager", 
      "waist", 
      "record", 
      "physical activity pattern", 
      "period", 
      "blood", 
      "urine sample", 
      "examination", 
      "Electrocardiography", 
      "body composition", 
      "physical fitness", 
      "fitness", 
      "stage", 
      "heart rate", 
      "nutrient", 
      "certain protein", 
      "future study", 
      "nutrition", 
      "genetic study", 
      "health", 
      "exercise", 
      "disease", 
      "past decade", 
      "physical activity level", 
      "occupation", 
      "transition", 
      "Western lifestyle", 
      "Chinese population", 
      "wide range", 
      "variation", 
      "unparalleled opportunity", 
      "measurement technique", 
      "main obstacle", 
      "quantifying", 
      "complexity", 
      "individual component", 
      "moderate intensity", 
      "population-based cohort study", 
      "cohort study", 
      "specific objective", 
      "current study", 
      "instrument", 
      "objective measure", 
      "activity monitor", 
      "aerobic fitness", 
      "parameter", 
      "specific marker", 
      "TNF-a", 
      "variable", 
      "association", 
      "anti-inflammatory drug", 
      "recent infection"
    ], 
    "name": "Physical Activity and Its Components in Relation to Plasma Inflammatory Markers of Cancer Risk Among Chinese Adults", 
    "sameAs": [
      "https://app.dimensions.ai/details/clinical_trial/NCT00521651"
    ], 
    "sdDataset": "clinical_trials", 
    "sdDatePublished": "2019-03-07T15:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "file:///pack/app/us_ct_data_00004.json", 
    "sponsor": [
      {
        "id": "https://www.grid.ac/institutes/grid.48336.3a", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.410305.3", 
        "type": "Organization"
      }, 
      {
        "id": "https://www.grid.ac/institutes/grid.152326.1", 
        "type": "Organization"
      }
    ], 
    "startDate": "2005-08-01T00:00:00Z", 
    "subjectOf": [
      {
        "id": "sg:pub.10.1023/a:1008853601471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014040326", 
          "https://doi.org/10.1023/a:1008853601471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/131.3.871s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074780240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074803696", 
        "type": "CreativeWork"
      }
    ], 
    "type": "MedicalStudy", 
    "url": "https://clinicaltrials.gov/show/NCT00521651"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/clinicaltrial.NCT00521651'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/clinicaltrial.NCT00521651'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/clinicaltrial.NCT00521651'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/clinicaltrial.NCT00521651'


 

This table displays all metadata directly associated to this object as RDF triples.

120 TRIPLES      15 PREDICATES      108 URIs      97 LITERALS      1 BLANK NODES

Subject Predicate Object
1 sg:clinicaltrial.NCT00521651 schema:about anzsrc-for:3177
2 schema:description This protocol is a sub-study of the ongoing "Protect Health and Reduce Cancer Risk" study conducted in Shanghai, China, and sponsored by the Shanghai Cancer Institute, Vanderbilt University, and the National Cancer Institute. The parent study is designed to examine the relationship of diet, lifestyle, occupational, and environmental risk factors, as well as genetic variation, to cancer incidence in a large cohort of men in women between 40 and 70 years of age. The current sub-study will assess the validity and reliability of a new physical activity questionnaire for use in the parent study and to evaluate whether different types of activity and the frequency, intensity, and duration of activity are associated with markers that have been linked to cancer risk, such as C-reactive protein, interleukin 6 and soluble tumor necrosis factor alpha. Participants in the current 12-month study are selected from among men and women participating in the "Protect Health and Reduce Cancer Risk" study. Participants keep a diary of their physical activity and complete two 30-minute interviews about their physical activity, one at the beginning and one at the end of the study period. Every 3 months for 7 consecutive days, they wear a pager-sized activity monitor on their waist that records their physical activity patterns during that period of time. They provide blood and urine samples four times during the study and, at the end of the study, undergo a health examination that includes an electrocardiogram, body composition measurement, and physical fitness test. The fitness test is a step-test consisting of 3-minute stages in which the subject successively increases the stepping speed until reaching 85 percent of his or her predicted maximal heart rate. Blood and urine samples are analyzed for levels of nutrients and certain proteins, and are stored for future studies related to nutrition and physical activity and possibly for genetic studies related to health, nutrition, exercise, or disease. Detailed Description In the past decade, China has experienced fundamental decreases in the populations' physical activity levels, due to increasingly sedentary occupations and lifestyles. However, the transition to a Western lifestyle has not reached the entire Chinese population. The resulting wide range of between-person variation in physical activity provides an unparalleled opportunity for physical activity studies. Although physical activity measurement techniques have evolved considerably over the past years, the main obstacle in quantifying physical activity is the complexity of precisely measuring its individual components, particularly low to moderate-intensity activities. Recently, investigators at Vanderbilt University, the Shanghai Cancer Institute, and the DCEG initiated two prospective population-based cohort studies: the Shanghai Women's Cohort and the Shanghai Men's Cohort. The aim of these studies is to prospectively examine the relations of diet, lifestyle, occupational, and environmental risk factors, as well as genetic variation, to cancer incidence among 75,000 women and 73,000 men, aged 40 to 70 years old, and residing in Shanghai, China. We propose to conduct a study among 600 women and men participating in these two cohort studies. The specific objectives of the current study are to develop a comprehensive physical activity questionnaire and to assess the validity and reliability of this instrument in the Shanghai cohorts using objective measures of physical activity/physical fitness: activity monitors, and the Modified Canadian Aerobic Fitness Test. In addition, we intend to evaluate whether different types and parameters of physical activity are associated with circulating levels of specific inflammatory markers that have been linked to cancer risk. The specific markers are C-reactive protein (CRP), interleukin 6 (IL-6), and soluble tumor necrosis factor alpha (TNF-a). The impact of potentially confounding variables of the association between physical activity and inflammatory markers, such as recent exercise, use of anti-inflammatory drugs, and current or recent infections, will be carefully accounted for in the analysis.
3 schema:keywords C-reactive protein
4 Cancer Institute
5 China
6 Chinese population
7 Electrocardiography
8 Interleukin-6
9 Life Style
10 Motor Activity
11 National Cancer Institute
12 Reproducibility of Result
13 Shanghai
14 TNF-a
15 Tumor Necrosis Factor-alpha
16 Vanderbilt University
17 Western lifestyle
18 activity monitor
19 adult
20 aerobic fitness
21 age
22 anti-inflammatory drug
23 association
24 beginning
25 blood
26 body composition
27 cancer incidence
28 cancer risk
29 certain protein
30 cohort study
31 complexity
32 component
33 current study
34 diet
35 different type
36 disease
37 duration
38 environmental risk factor
39 examination
40 exercise
41 fitness
42 frequency
43 future study
44 genetic study
45 genetic variation
46 health
47 heart rate
48 individual component
49 inflammatory marker
50 instrument
51 intensity
52 interview
53 large cohort
54 main obstacle
55 marker
56 measurement technique
57 men
58 moderate intensity
59 nutrient
60 nutrition
61 objective measure
62 occupation
63 pager
64 parameter
65 parent study
66 past decade
67 period
68 physical activity level
69 physical activity pattern
70 physical activity questionnaire
71 physical fitness
72 plasma
73 population-based cohort study
74 protocol
75 quantifying
76 recent infection
77 record
78 relation
79 specific marker
80 specific objective
81 stage
82 study period
83 sub-study
84 transition
85 unparalleled opportunity
86 urine sample
87 variable
88 variation
89 waist
90 wide range
91 woman
92 schema:name Physical Activity and Its Components in Relation to Plasma Inflammatory Markers of Cancer Risk Among Chinese Adults
93 schema:sameAs https://app.dimensions.ai/details/clinical_trial/NCT00521651
94 schema:sdDatePublished 2019-03-07T15:22
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N85cd98f737a34741a67b1fece22ff42f
97 schema:sponsor https://www.grid.ac/institutes/grid.152326.1
98 https://www.grid.ac/institutes/grid.410305.3
99 https://www.grid.ac/institutes/grid.48336.3a
100 schema:startDate 2005-08-01T00:00:00Z
101 schema:subjectOf sg:pub.10.1023/a:1008853601471
102 https://app.dimensions.ai/details/publication/pub.1074803696
103 https://doi.org/10.1093/jn/131.3.871s
104 schema:url https://clinicaltrials.gov/show/NCT00521651
105 sgo:license sg:explorer/license/
106 sgo:sdDataset clinical_trials
107 rdf:type schema:MedicalStudy
108 N85cd98f737a34741a67b1fece22ff42f schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 anzsrc-for:3177 schema:inDefinedTermSet anzsrc-for:
111 rdf:type schema:DefinedTerm
112 sg:pub.10.1023/a:1008853601471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014040326
113 https://doi.org/10.1023/a:1008853601471
114 rdf:type schema:CreativeWork
115 https://app.dimensions.ai/details/publication/pub.1074803696 schema:CreativeWork
116 https://doi.org/10.1093/jn/131.3.871s schema:sameAs https://app.dimensions.ai/details/publication/pub.1074780240
117 rdf:type schema:CreativeWork
118 https://www.grid.ac/institutes/grid.152326.1 schema:Organization
119 https://www.grid.ac/institutes/grid.410305.3 schema:Organization
120 https://www.grid.ac/institutes/grid.48336.3a schema:Organization
 




Preview window. Press ESC to close (or click here)


...