A PRogram to Optimize the quality of Antibiotic use within the hospital - impact on antibiotic consumption, cost savings and ... View Homepage


Ontology type: schema:MedicalStudy     


Clinical Trial Info

YEARS

2007-2009

ABSTRACT

Background and study aims Antibiotics are a very large and growing percentage of pharmaceutical spending that can reach 30% of the cost of a hospital pharmacy. The excessive and inappropriate use of antibiotics is of great importance due to the cost and undesirable side effects, and the growing development of resistance to antibiotics. Control measures aimed at optimizing the prescription of antibiotics can generate significant savings, improve patients’ prognosis and reduce resistance to antibiotics. As a result, in recent years, numerous hospitals have designed different models to achieve this objective. The aim of this study is to assess the impact of an intervention to optimize the use of intervention in a hospital. Who can participate? Patients admitted to General Surgery, Pneumology and Endocrinology at the Hospital Universitario Marqués de Valdecilla (Spain), and prescribed antibiotics by their doctors for more than 3 days What does the study involve? The participating clinical units are randomly allocated to either receive the intervention or to not receive the intervention. The intervention consists of treatment recommendations written by an infectious diseases physician based on international treatment guidelines, adapted after examination of patients, clinical records and microbiological data (if any) for each patient in the intervention group. Written recommendations (in specifically designed study forms) are inserted into the patient’s records to make them available to treating physicians, with a statement indicating their availability for oral consultation if desired. Consultation is also available as part of daily practice for physicians treating patients in the non-intervention group (without insertion of written recommendations), but in this case the patient is withdrawn from the study. Demographic and clinical data (including other illnesses), antibiotic treatment given, reason for antibiotic treatment, imaging and microbiological data, and microbiological and clinical outcomes are recorded for patients in both groups. Length of hospitalization (time from admission to discharge/death) is calculated. On the 7th day, adherence to the treatment recommendation is assessed. The microbiological and clinical outcomes of infections are assessed at the end of antibiotic treatment and at discharge. What are the possible benefits and risks of participating? Not provided at time of registration Where is the study run from? Training and Research Institute, Marqués de Valdecilla (Spain) When is the study starting and how long is it expected to run for? January 2007 to June 2009 Who is funding the study? 1. Ministry of Health (Spain) 2. Training and Research Institute Marqués de Valdecilla (Spain) Who is the main contact? Prof. M. Carmen Fariñas More... »

URL

http://www.isrctn.com/ISRCTN83234896

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